Lophotoxin

Product Code:

TAR-T32870

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

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Code	Size	Price

TAR-T32870-5mg

5mg

£850.00

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Quantity:

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Further Information

Bioactivity:

Lophotoxin belongs to the cembrene class of diterpenoids; neuromuscular toxin isolated from several pacific gorgonians of the genus Lophogorgia.

CAS:

78697-56-0

Formula:

C22H24O8

Molecular Weight:

416.426

Purity:

0.98

SMILES:

[H][C@@]12O[C@]1(C)C[C@@]1([H])OC(=O)[C@@]3(O[C@]13[H])[C@H](C[C@@H](Cc1oc2cc1C=O)C(C)=C)OC(C)=O

Documents

References

1. Groebe DR, Abramson SN. Lophotoxin is a slow binding irreversible inhibitor of nicotinic acetylcholine receptors. J Biol Chem. 1995 Jan 6;270(1):281-6. PubMed PMID: 7814387. 2. Atchison WD, Narahashi T, Vogel SM. Endplate blocking actions of lophotoxin. Br J Pharmacol. 1984 Jul;82(3):667-72. PubMed PMID: 6146369; PubMed Central PMCID: PMC1986998. 3. Fenical W, Okuda RK, Bandurraga MM, Culver P, Jacobs RS. Lophotoxin: a novel neuromuscular toxin from Pacific sea whips of the genus Lophogorgia. Science. 1981 Jun 26;212(4502):1512-4. PubMed PMID: 6112796. 4. Sorenson EM, Culver P, Chiappinelli VA. Lophotoxin: selective blockade of nicotinic transmission in autonomic ganglia by a coral neurotoxin. Neuroscience. 1987 Mar;20(3):875-84. PubMed PMID: 2885781.