TargetMol

MK-0686

Product Code:
 
TAR-T33421
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33421-1mg1mg£224.00
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TAR-T33421-5mg5mg£448.00
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TAR-T33421-10mg10mg£624.00
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TAR-T33421-25mg25mg£938.00
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TAR-T33421-50mg50mg£1,243.00
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TAR-T33421-100mg100mg£1,645.00
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Quantity:
TAR-T33421-500mg500mg£3,227.00
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  • Further Information
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Further Information

Bioactivity:
MK-0686 is an antagonist of bradykinin B1 receptor.
CAS:
578727-68-1
Formula:
C22H19ClF4N2O4
Molecular Weight:
486.85
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(CC2)NC(=O)C(F)(F)F)c(F)c1
Target:
Bradykinin Receptor

References

Tang C, Carr BA, Poignant F, Ma B, Polsky-Fisher SL, Kuo Y, Strong-Basalyga K, Norcross A, Richards K, Eisenhandler R, Carlini EJ, Di Marco CN, Kuduk SD, Yu NX, Raab CE, Rushmore T, Frederick CB, Bock MG, Prueksaritanont T. CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)a mino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist. J Pharmacol Exp Ther. 2008 Jun;325(3):935-46. Kuduk SD, et al. Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists. J Med Chem. 2007 Jan 25;50(2):272-82.