TargetMol

MK-142 dimethanesulfonate

Product Code:
 
TAR-T33426
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T33426-5mg5mg£850.00
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TAR-T33426-50mg50mg£1,661.00
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TAR-T33426-100mg100mg£2,079.00
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Further Information

Bioactivity:
MK-142 dimethyl sulfonate is a biologic active agent with antiarrhythmic properties, and the content of MK-142 is relatively high in cardiac muscle compared to that in skeletal muscle, indicating that the substance tested has a high affinity with cardiac muscle.
CAS:
42794-63-8
Formula:
C22H32N2O6
Molecular Weight:
420.506
Purity:
0.98
SMILES:
COc1ccc(OCC(O)CNCCNCC(O)COc2ccc(OC)cc2)cc1

References

Ernest K. Pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part II. Antiarrhythmic properties, the influence on heart and some hemodynamic parameters. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):381-98. PubMed PMID: 1166019. Nowicka A, Prussak T, Szukalski B. Metabolism of some ethylenediamine derivatives with antiarrhythmic properties. I. Absorption, distribution in tissues and excretion of 14-C labelled N, N'-bis-[3-(p-methoxyphenoxy)-2-hydroxypropyl]-ethylenediamine dimethanesulphonate (MK-142) in rats. Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):113-20. PubMed PMID: 168561. Noyszewska-Skibi?ska I, Nowicka A, Ernest K, Nowicka J. Biochemical, morphochemical and pharmacodynamic evaluation of accumulation of ethylenediamine derivatives (ROM-203, MK-142) in some rat tissues. Mater Med Pol. 1977 Jul-Sep;9(3):216-24. PubMed PMID: 926836. Ernest K. The pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part I. General pharmacological properties. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):363-79. PubMed PMID: 241067.