TargetMol

Neostigmine Iodide

Product Code:
 
TAR-T33638
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33638-5mg5mg£850.00
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TAR-T33638-50mg50mg£1,661.00
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Quantity:
TAR-T33638-100mg100mg£2,079.00
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Further Information

Bioactivity:
Neostigmine Iodide is a parasympathic compound used as a reversible acetylcholinesterase inhibitor to improve muscle tone in patients with myasthenia gravis and in routine anesthesia to reverse the effects of non-depolarizing muscle relaxants such as rocuronium and vecuronium at the end of surgery. It can also be used for urinary retention caused by general anesthesia and for the treatment of poison drugs.
CAS:
1212-37-9
Formula:
C12H19IN2O2
Molecular Weight:
350.2
Purity:
0.98
SMILES:
[I-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C

References

Berk? S, Sz?cs KF, Bal?zs B, Cs?nyi E, Varju G, Sztojkov-Ivanov A, Budai-Sz?cs M, B?ta J, G?sp?r R. Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration. Drug Des Devel Ther. 2016 May 19;10:1695-701. doi: 10.2147/DDDT.S102959. eCollection 2016. PubMed PMID: 27274203; PubMed Central PMCID: PMC4876850. Wu J, Jin T, Wang H, Li ST. Sepsis Strengthens Antagonistic Actions of Neostigmine on Rocuronium in a Rat Model of Cecal Ligation and Puncture. Chin Med J (Engl). 2016 20th Jun;129(12):1477-1482. doi: 10.4103/0366-6999.183420. PubMed PMID: 27270546; PubMed Central PMCID: PMC4910374. Sharma A, Kumar NJ, Azharuddin M, Mohan LC, Ramachandran G. Evaluation of low-dose dexmedetomidine and neostigmine with bupivacaine for postoperative analgesia in orthopedic surgeries: A prospective randomized double-blind study. J Anaesthesiol Clin Pharmacol. 2016 Apr-Jun;32(2):187-91. doi: 10.4103/0970-9185.173355. PubMed PMID: 27275047; PubMed Central PMCID: PMC4874072. Sen A, Erdivanli B, Tomak Y, Pergel A. Reversal of neuromuscular blockade with sugammadex or neostigmine/atropine: Effect on postoperative gastrointestinal motility. J Clin Anesth. 2016 Aug;32:208-13. doi: 10.1016/j.jclinane.2016.03.010. Epub 2016 Apr 20. PubMed PMID: 27290978.