TargetMol

NK 611

Product Code:
 
TAR-T33695
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33695-5mg5mg£850.00
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Further Information

Bioactivity:
NK 611 is a new semisynthetic analogue of etoposide and has been found to be more potent against several cancer cell lines in vitro than etoposide.
CAS:
105760-98-3
Formula:
C31H38ClNO12
Molecular Weight:
652.09
Purity:
0.98
SMILES:
Cl.[H][C@]12COC(=O)[C@]1([H])[C@@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@@H]2COC(C)O[C@H]2[C@H](O)[C@H]1N(C)C

References

Daley L, Guminski Y, Demerseman P, Kruczynski A, Eti?vant C, Imbert T, Hill BT, Monneret C. Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem. 1998 Nov 5;41(23):4475-85. PubMed PMID: 9804687. H?ttmann A, Mross K, Hossfeld DK. Determination of the new podophyllotoxin derivative NK 611 in plasma by high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1993 Oct 29;620(2):233-8. PubMed PMID: 8300791. Mross K, H?ttmann A, Herbst K, Hanauske AR, Schilling T, Manegold C, Burk K, Hossfeld DK. Pharmacokinetics and pharmacodynamics of the new podophyllotoxin derivative NK 611. A study by the AIO groups PHASE-I and APOH. Cancer Chemother Pharmacol. 1996;38(3):217-24. PubMed PMID: 8646795. Hanauske AR, W?ster KC, Lehmer A, Rotter M, Schneider P, Kaeser-Fr?hlich A, Rastetter J, Depenbrock H. Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro. Eur J Cancer. 1995 Sep;31A(10):1677-81. PubMed PMID: 7488424.