TargetMol

NLP 1

Product Code:
 
TAR-T33700
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33700-5mg5mg£850.00
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TAR-T33700-50mg50mg£1,661.00
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Quantity:
TAR-T33700-100mg100mg£2,079.00
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Further Information

Bioactivity:
NLP 1 is a DNA intercalating hypoxic cell radiosensitizer and cytotoxin.
CAS:
121064-77-5
Formula:
C19H17BrN4O2
Molecular Weight:
413.275
Purity:
0.98
SMILES:
[Br-].[O-][N+](=O)c1nccn1CCC[n+]1cc2ccccc2c2ccccc12

References

Cowan DS, McClelland RA, Rauth AM. Isolation and characterization of a cell line resistant to 5-[3-(2-nitro-1-imidazoyl)-propyl]-phenanthridinium bromide (2-NLP-3), a DNA-intercalating hypoxic cell radiosensitizer and cytotoxin. Biochem Pharmacol. 1995 Jun 29;50(1):61-8. PubMed PMID: 7605346. Panicucci R, Heal R, Laderoute K, Cowan D, McClelland RA, Rauth AM. NLP-1: a DNA intercalating hypoxic cell radiosensitizer and cytotoxin. Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):1039-43. PubMed PMID: 2703383. Cowan DS, Kanagasabapathy VM, McClelland RA, Rauth AM. Mechanistic studies of enhanced in vitro radiosensitization and hypoxic cell cytotoxicity by targeting radiosensitizers to DNA via intercalation. Int J Radiat Oncol Biol Phys. 1992;22(3):541-4. PubMed PMID: 1735693. Buchko GW, Weinfeld M. DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation. Radiat Res. 2002 Sep;158(3):302-10. PubMed PMID: 12175307.