TargetMol

Odelepran

Product Code:
 
TAR-T33780
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33780-5mg5mg£850.00
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Quantity:
TAR-T33780-50mg50mg£1,661.00
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Quantity:
TAR-T33780-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Odelepran (LY2196044) is an opioid receptor antagonist under development for the treatment of alcohol dependence.
CAS:
676501-25-0
Formula:
C20H24FN3O3
Molecular Weight:
373.428
Purity:
0.98
SMILES:
NC(=O)c1ccc(Oc2ccc(CNCCC3CCOCC3)cc2F)nc1

References

Wong CJ, Witcher J, Mallinckrodt C, Dean RA, Anton RF, Chen Y, Fijal BA, Ouyang H, Dharia S, Sundseth SS, Schuh KJ, Kinon BJ. A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence. Alcohol Clin Exp Res. 2014 Feb;38(2):511-20. doi: 10.1111/acer.12257. Epub 2013 Sep 6. PubMed PMID: 24010675. Hillemacher T, Heberlein A, Muschler MA, Bleich S, Frieling H. Opioid modulators for alcohol dependence. Expert Opin Investig Drugs. 2011 Aug;20(8):1073-86. doi: 10.1517/13543784.2011.592139. Epub 2011 Jun 9. Review. PubMed PMID: 21651459. Ding X, He M, Kulkarni R, Patel N, Zhang X. Investigation of clinical pharmacokinetic variability of an opioid antagonist through physiologically based absorption modeling. J Pharm Sci. 2013 Aug;102(8):2859-74. doi: 10.1002/jps.23629. Epub 2013 Jun 11. PubMed PMID: 23761048.