TargetMol

PACA

Product Code:
 
TAR-T33858
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33858-5mg5mg£850.00
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Quantity:
TAR-T33858-50mg50mg£1,661.00
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Quantity:
TAR-T33858-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
PACA, (N-propargyl Caffeamide)enhances NGF-induced neurite growth and reduces 6-hydroxydopamine neurotoxicity in neuron cultures. Parkinson's disease (PD) is associated with insufficient production of nerve growth factor (NGF).
CAS:
1431724-30-9
Formula:
C12H11NO3
Molecular Weight:
217.224
Purity:
0.98
SMILES:
Oc1ccc(C=CC(=O)NCC#C)cc1O

References

Yang C, Zhao J, Cheng Y, Le XC, Rong J. N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Toxicity by Activating the Nrf2/HO-1 Pathway. ACS Chem Neurosci. 2015 Sep 16;6(9):1560-9. doi: 10.1021/acschemneuro.5b00115. Epub 2015 Jul 16. PubMed PMID: 26147318. Luo D, Zhao J, Cheng Y, Lee SM, Rong J. N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP(+)-Induced Neurons via Promoting the Conversion of proNGF to NGF. Mol Neurobiol. 2017 Mar 21. doi: 10.1007/s12035-017-0486-6. [Epub ahead of print] PubMed PMID: 28321769.