TargetMol

PF-06445974

Product Code:
 
TAR-T33947
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T33947-100mg100mgEnquire
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Further Information

Bioactivity:
PF-06445974 has good selectivity for PDE4D, excellent brain permeability, and has a high level of specific binding in the "cold tracer" study.
CAS:
2055776-17-3
Formula:
C20H15FN4O
Molecular Weight:
346.365
Purity:
0.98
SMILES:
Fc1cc(ccc1C#N)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1

References

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging Lei Zhang, Laigao Chen, Elizabeth M. Beck, Thomas A. Chappie, Richard V. Coelho, Shawn D. Doran, Kuo-Hsien Fan, John M. Humphrey, Zoe Hughes, Kyle Kuszpit, Erik A. Lachapelle, John T. Lazzaro, Robert J. Mather, Nandini C. Patel, Marc B. Skaddan, Simone Sciabola, Patrick R. Verhoest, Joseph M. Young, Kenneth Zasadny, and Anabella Villalobos Publication Date (Web): September 28, 2017 (Article) doi: 10.1021/acs.jmedchem.7b01050