Phendioxan

Quaglia W, Santoni G, Pigini M, Piergentili A, Gentili F, Buccioni M, Mosca M, Lucciarini R, Amantini C, Nabissi MI, Ballarini P, Poggesi E, Leonardi A, Giannella M. Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation. J Med Chem. 2005 Dec 1;48(24):7750-63. PubMed PMID: 16302814. Quaglia W, Giannella M, Marucci G, Piergentili A, Pigini M, Tayebati SK, Melchiorre C. Structure-activity relationships in 1,4-benzodioxan-related compounds. 5. Effects of modification of the side chain on alpha-adrenoreceptor blocking activity. Farmaco. 1996 Jan;51(1):27-32. PubMed PMID: 8721758. Quaglia W, Pigini M, Piergentili A, Giannella M, Gentili F, Marucci G, Carrieri A, Carotti A, Poggesi E, Leonardi A, Melchiorre C. Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes. J Med Chem. 2002 Apr 11;45(8):1633-43. PubMed PMID: 11931617. Carrieri A, Piergentili A, Del Bello F, Giannella M, Pigini M, Leonardi A, Fanelli F, Quaglia W. Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel ?1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and ?1d computational study. Bioorg Med Chem. 2010 Oct 1;18(19):7065-77. doi: 10.1016/j.bmc.2010.08.002. Epub 2010 Aug 6. PubMed PMID: 20801662.