TargetMol

R214127

Product Code:
 
TAR-T34243
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34243-5mg5mg£850.00
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TAR-T34243-50mg50mg£1,661.00
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Quantity:
TAR-T34243-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
R214127 is a new type of mGlu1 receptor high-affinity radioligand.
CAS:
409345-76-2
Formula:
C20H17NO2
Molecular Weight:
303.361
Purity:
0.98
SMILES:
O=C(Cc1ccccc1)c1ccc2nc3OCCCc3cc2c1

References

Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. PubMed PMID: 12695537. Simon L, Toth J, Molnar L, Agoston DV. MRI analysis of mGluR5 and mGluR1 antagonists, MTEP and R214127 in the cerebral forebrain of awake, conscious rats. Neurosci Lett. 2011 Nov 14;505(2):155-9. doi: 10.1016/j.neulet.2011.10.010. Epub 2011 Oct 12. PubMed PMID: 22015763. Lavreysen H, Pereira SN, Leysen JE, Langlois X, Lesage AS. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr;46(5):609-19. PubMed PMID: 14996538.