TargetMol

Rovatirelin

Product Code:
 
TAR-T34399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34399-5mg5mg£1,010.00
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TAR-T34399-50mg50mg£1,982.00
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Quantity:
TAR-T34399-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
Rovatirelin, also known as S-0373, is a novel synthetic agent that mimics the actions of thyrotropin-releasing hormone (TRH). Rovatirelin binds to the human TRH receptor with higher affinity (Ki=702nM) than taltirelin (Ki=3877nM). Rovatirelin increased the spontaneous firing of action potentials in the acutely isolated noradrenergic neurons of rat locus coeruleus (LC). Rovatirelin increased locomotor activity. Rovatirelin may have an orally effective therapeutic potential in patients with SCD.
CAS:
204386-76-5
Formula:
C17H24N4O4S
Molecular Weight:
380.46
Purity:
0.98
SMILES:
C[C@@H]1CCCN1C(=O)[C@H](CCc1cscn1)NC(=O)[C@H]1NC(=O)O[C@H]1C

References

Ijiro T, Nakamura K, Ogata M, Inada H, Kiguchi S, Maruyama K, Nabekura J, Kobayashi M, Ishibashi H. Effect of rovatirelin, a novel thyrotropin-releasing hormone analog, on the central noradrenergic system. Eur J Pharmacol. 2015 Aug 15;761:413-22. doi: 10.1016/j.ejphar.2015.05.047. Epub 2015 Jul 2. PubMed PMID: 26142830.