TargetMol

2-PMPA

Product Code:
 
TAR-T3440
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3440-5mg5mg£119.00
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TAR-T3440-10mg10mg£146.00
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TAR-T3440-25mg25mg£222.00
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TAR-T3440-50mg50mg£290.00
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TAR-T3440-100mg100mg£434.00
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This product comes from: United States.
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Further Information

Bioactivity:
2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) (IC50=300 pM).
CAS:
173039-10-6
Formula:
C6H11O7P
Molecular Weight:
226.121
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
OC(=O)CCC(CP(O)(O)=O)C(O)=O
Target:
Carboxypeptidase

References

Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51(7-8):1163-71. Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26(1):1-15. Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30. Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal. 2014 Jan;88:162-9.