TargetMol

RSU 1131

Product Code:
 
TAR-T34422
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T34422-5mg5mg£850.00
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Further Information

Bioactivity:
RSU 1131 is a nitroimidazole-aziridine.
CAS:
88876-89-5
Formula:
C9H14N4O3
Molecular Weight:
226.236
Purity:
0.98
SMILES:
CC1CN1CC(O)Cn1ccnc1[N+]([O-])=O

References

Jenner TJ, Sapora O, O'Neill P, Fielden EM. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochem Pharmacol. 1988 Oct 15;37(20):3837-42. PubMed PMID: 3190731. Walling J, Stratford IJ, Adams GE, Stephens MA. Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Apr;53(4):641-9. PubMed PMID: 3258298. O'Neill P, McNeil SS, Jenkins TC. Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochem Pharmacol. 1987 Jun 1;36(11):1787-92. PubMed PMID: 3579973. Sapora O, Paone A, Maggi A, Jenner TJ, O'Neill P. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione. Biochem Pharmacol. 1992 Oct 6;44(7):1341-7. PubMed PMID: 1417957.