TargetMol

S2366 HCl

Product Code:
 
TAR-T34473
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34473-5mg5mg£850.00
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Further Information

Bioactivity:
S 2366 is a chromogenic substrate for Factor XI in plasma.
CAS:
127428-47-1
Formula:
C22H31ClN8O6
Molecular Weight:
538.99
Purity:
0.98
SMILES:
Cl.NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCC(=O)N1)C(=O)Nc1ccc(cc1)[N+]([O-])=O

References

Li QQ, Yang FQ, Wang YZ, Wu ZY, Xia ZN, Chen H. Evaluation of thrombin inhibitory activity of catechins by online capillary electrophoresis-based immobilized enzyme microreactor and molecular docking. Talanta. 2018 Aug 1;185:16-22. doi: 10.1016/j.talanta.2018.03.049. Epub 2018 Mar 18. PubMed PMID: 29759183. Marcinkiewicz MM, Sinha D, Walsh PN. Productive recognition of factor IX by factor XIa exosites requires disulfide linkage between heavy and light chains of factor XIa. J Biol Chem. 2012 Feb 24;287(9):6187-95. doi: 10.1074/jbc.M111.291989. Epub 2011 Dec 29. PubMed PMID: 22207756; PubMed Central PMCID: PMC3307291. Geng Y, Verhamme IM, Messer A, Sun MF, Smith SB, Bajaj SP, Gailani D. A sequential mechanism for exosite-mediated factor IX activation by factor XIa. J Biol Chem. 2012 Nov 2;287(45):38200-9. doi: 10.1074/jbc.M112.376343. Epub 2012 Sep 7. PubMed PMID: 22961984; PubMed Central PMCID: PMC3488089. L?vgren A, Deinum J, Ros?n S, Bryngelhed P, Ros?n P, Hansson KM. Characterization of thrombin derived from human recombinant prothrombin. Blood Coagul Fibrinolysis. 2015 Jul;26(5):545-55. doi: 10.1097/MBC.0000000000000289. PubMed PMID: 25811451; PubMed Central PMCID: PMC4500656.