TargetMol

Spicamycin

Product Code:
 
TAR-T34694
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34694-5mg5mg£3,018.00
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TAR-T34694-50mg50mg£5,998.00
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Quantity:
TAR-T34694-100mg100mg£8,584.00
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This product comes from: United States.
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Further Information

Bioactivity:
Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).
CAS:
87099-85-2
Formula:
C30H51N7O7
Molecular Weight:
621.78
Purity:
0.98
SMILES:
CC(C)CCCCCCCCCCCCC(=O)NCC(=O)NC1C(O)C(O)C(Nc2ncnc3nc[nH]c23)OC1C(O)CO

References

Sukkurwala AQ, Adjemian S, Senovilla L, Michaud M, Spaggiari S, Vacchelli E, Baracco EE, Galluzzi L, Zitvogel L, Kepp O, Kroemer G. Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set. Oncoimmunology. 2014 Apr 16;3:e28473. eCollection 2014. PubMed PMID: 25050214; PubMed Central PMCID: PMC4063139. Price NP, Furukawa T, Cheng F, Qi J, Chen W, Crich D. Biosynthesis of 4-aminoheptose 2-epimers, core structural components of the septacidins and spicamycins. J Antibiot (Tokyo). 2014 May;67(5):405-14. doi: 10.1038/ja.2014.15. Epub 2014 Mar 19. PubMed PMID: 24643053. Weinstein SM, Abernethy AP, Spruill SE, Pike IM, True Kelly A, Jett LG. A spicamycin derivative (KRN5500) provides neuropathic pain relief in patients with advanced cancer: a placebo-controlled, proof-of-concept trial. J Pain Symptom Manage. 2012 Apr;43(4):679-93. doi: 10.1016/j.jpainsymman.2011.05.003. Epub 2011 Oct 7. PubMed PMID: 21983265. Tang W, Guo Z, Cao Z, Wang M, Li P, Meng X, Zhao X, Xie Z, Wang W, Zhou A, Lou C, Chen Y. d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2818-2823. doi: 10.1073/pnas.1711665115. Epub 2018 Feb 26. PubMed PMID: 29483275; PubMed Central PMCID: PMC5856511.