TargetMol

SRI-29132

Product Code:
 
TAR-T34706
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34706-5mg5mg£850.00
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Quantity:
TAR-T34706-50mg50mg£1,661.00
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Quantity:
TAR-T34706-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.
CAS:
1482305-44-1
Formula:
C18H21N5OS2
Molecular Weight:
387.52
Purity:
0.98
SMILES:
CCC(Sc1ccc2nnc(-c3cccs3)n2n1)C(=O)N1CCCCC1

References

Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. PubMed PMID: 25228699; PubMed Central PMCID: PMC4239640.