TargetMol

Symplostatin 1

Product Code:
 
TAR-T34758
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34758-5mg5mg£1,653.00
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TAR-T34758-50mg50mg£3,267.00
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Quantity:
TAR-T34758-100mg100mg£4,488.00
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This product comes from: United States.
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Further Information

Bioactivity:
Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.
CAS:
212007-18-6
Formula:
C43H70N6O6S
Molecular Weight:
799.13
Purity:
0.98
SMILES:
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)[C@@H](C(C)C)C(=O)NC(=O)[C@H]([C@@H](C)CC)N(C)C

References

Salvador LA, Paul VJ, Luesch H. Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. J Nat Prod. 2010 Sep 24;73(9):1606-9. doi: 10.1021/np100467d. Erratum in: J Nat Prod. 2016 Feb 26;79(2):452. PubMed PMID: 20806908; PubMed Central PMCID: PMC2965599. Salvador-Reyes LA, Engene N, Paul VJ, Luesch H. Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. J Nat Prod. 2015 Mar 27;78(3):486-92. doi: 10.1021/np500931q. Epub 2015 Jan 30. PubMed PMID: 25635943; PubMed Central PMCID: PMC4724867. Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Paul VJ, Mooberry SL, Corbett TH, Valeriote FA. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. J Nat Prod. 1998 Sep;61(9):1075-7. PubMed PMID: 9748368. Mooberry SL, Leal RM, Tinley TL, Luesch H, Moore RE, Corbett TH. The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. Int J Cancer. 2003 Apr 20;104(4):512-21. PubMed PMID: 12584751.