TargetMol

VMY-2-95

Product Code:
 
TAR-T35068
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35068-5mg5mg£850.00
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TAR-T35068-50mg50mg£1,661.00
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Quantity:
TAR-T35068-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
VMY-2-95 is an α4β2 nicotinic acetylcholine receptors (nAChRs) selective desensitizer.
CAS:
1434047-61-6
Formula:
C17H16N2O
Molecular Weight:
264.328
Purity:
0.98
SMILES:
C(Oc1cncc(c1)C#Cc1ccccc1)[C@@H]1CCN1

References

Kong H, Song JK, Yenugonda VM, Zhang L, Shuo T, Cheema AK, Kong Y, Du GH, Brown ML. Preclinical studies of the potent and selective nicotinic ?4?2 receptor ligand VMY-2-95. Mol Pharm. 2015 Feb 2;12(2):393-402. doi: 10.1021/mp5003569. Epub 2015 Jan 20. PubMed PMID: 25533629; PubMed Central PMCID: PMC4319692. Levin ED, Sexton HG, Gordon K, Gordon CJ, Xiao Y, Kellar KJ, Yenugonda VM, Liu Y, White MP, Paige M, Brown ML, Rezvani AH. Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor ?2-/- and ?7-/- mice. Eur J Pharmacol. 2013 Oct 15;718(1-3):167-72. doi: 10.1016/j.ejphar.2013.08.037. Epub 2013 Sep 12. PubMed PMID: 24036108; PubMed Central PMCID: PMC3844546. Yenugonda VM, Xiao Y, Levin ED, Rezvani AH, Tran T, Al-Muhtasib N, Sahibzada N, Xie T, Wells C, Slade S, Johnson JE, Dakshanamurthy S, Kong HS, Tomita Y, Liu Y, Paige M, Kellar KJ, Brown ML. Design, synthesis and discovery of picomolar selective ?4?2 nicotinic acetylcholine receptor ligands. J Med Chem. 2013 Nov 14;56(21):8404-21. doi: 10.1021/jm4008455. Epub 2013 Oct 18. PubMed PMID: 24047231. Rezvani AH, Slade S, Wells C, Yenugonda VM, Liu Y, Brown ML, Xiao Y, Kellar KJ, Levin ED. Differential efficacies of the nicotinic ?4?2 desensitizing agents in reducing nicotine self-administration in female rats. Psychopharmacology (Berl). 2017 Sep;234(17):2517-2523. doi: 10.1007/s00213-017-4641-6. Epub 2017 May 29. PubMed PMID: 28555315.