TargetMol

SHP099 hydrochloride

Product Code:
 
TAR-T3544
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3544-1mg1mg£96.00
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TAR-T3544-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T3544-5mg5mg£128.00
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TAR-T3544-10mg10mg£149.00
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TAR-T3544-25mg25mg£213.00
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TAR-T3544-50mg50mg£279.00
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TAR-T3544-100mg100mg£452.00
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Quantity:
TAR-T3544-500mg500mg£914.00
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This product comes from: United States.
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Further Information

Bioactivity:
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.
CAS:
2200214-93-1
Formula:
C16H20Cl3N5
Molecular Weight:
388.72
Pathway:
; Metabolism
Purity:
0.9962
SMILES:
Nc1nc(N2CCC(C)(N)CC2)cnc1c1cccc(Cl)c1Cl.Cl
Target:
Phosphatase;

References

Zheng M, Liu Y, Wu C, et al. Novel PROTACs for degradation of SHP2 protein. Bioorganic Chemistry. 2021, 110: 104788 Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82. Carmine Fedele, et al. SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models. bioRxiv. April 25, 2018. Qiu W Q, Ai W, Zhu F D, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radical Biology and Medicine. 2022, 179: 76-94. Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52.