TargetMol

O-7460

Product Code:
 
TAR-T35786
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T35786-5mg5mg£850.00
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Quantity:
TAR-T35786-50mg50mg£1,661.00
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Quantity:
TAR-T35786-100mg100mg£2,079.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM). It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 μM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 μM). At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.
CAS:
1572051-31-0
Formula:
C25H48FO5P
Molecular Weight:
478.626
Purity:
0.98
SMILES:
CCCCCCCCC=C/CCCCCCCC(=O)OC(COC(C)C)COP(C)(F)=O