TargetMol

JK184

Product Code:
 
TAR-T3588
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3588-5mg5mg£109.00
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TAR-T3588-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T3588-10mg10mg£133.00
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TAR-T3588-25mg25mg£214.00
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TAR-T3588-50mg50mg£319.00
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Quantity:
TAR-T3588-100mg100mg£518.00
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Quantity:
TAR-T3588-500mg500mg£1,058.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
CAS:
315703-52-7
Formula:
C19H18N4OS
Molecular Weight:
350.44
Pathway:
GPCR/G Protein; Stem Cells
Purity:
0.9937
SMILES:
CCOc1ccc(Nc2nc(cs2)-c2c(C)nc3ccccn23)cc1
Target:
Hedgehog/Smoothened

References

Colavito, S., Zou, M., Yan, Q., Nguyen, D., & Stern, D. (2014). Significance of glioma-associated oncogene homolog 1 (GLI1)expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF?B) pathway.?Breast Cancer Research,?16(5). doi: 10.1186/s13058-014-0444-4 Zhang N, et al. Biodegradable polymeric micelles encapsulated JK184 suppress tumor growth through inhibiting Hedgehog signaling pathway. Nanoscale. 2015 Feb 14;7(6):2609-24.