TargetMol

TNF- α-IN-2

Product Code:
 
TAR-T36097
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36097-5mg5mg£1,251.00
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TAR-T36097-50mg50mg£2,633.00
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TAR-T36097-100mg100mg£4,199.00
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This product comes from: United States.
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Further Information

Bioactivity:
TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis[1].
CAS:
2074702-04-6
Formula:
C25H21ClF2N6O
Molecular Weight:
494.92
Purity:
0.98
SMILES:
N/A

References

Xiao HY, et, al. Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF? Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches. J Med Chem. 2020 Dec 1.