TargetMol

Colchicoside

Product Code:
 
TAR-T36115
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36115-10mg10mg£129.00
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Quantity:
TAR-T36115-1mL1 mL * 10 mM (in DMSO)£147.00
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TAR-T36115-25mg25mg£187.00
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TAR-T36115-50mg50mg£269.00
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Quantity:
TAR-T36115-100mg100mg£368.00
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Further Information

Bioactivity:
Colchicoside is a glycoside form of 3-demethylcolchicine that has been found inG. superba.1Unlike cholchicine and 3-demethylcolchicine, colchicoside does not displace [3H]-colchicine from rat brain tubulinin vitrowhen used at a concentration of 25 μM.2Colchicoside (1 and 10 μM) increases levels of the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2E1 in primary human hepatocytes.3
CAS:
477-29-2
Formula:
C27H33NO11
Molecular Weight:
547.557
Purity:
0.98
SMILES:
COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c1OC

References

Dvor?k Z, Ulrichov? J, Modriansk? M, Maurel P. Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes. Acta Univ Palacki Olomuc Fac Med. 2000;143:47-50. Capistrano I R, et al. Coadministration of a Gloriosa superba extract improves the in vivo antitumoural activity of gemcitabine in a murine pancreatic tumour model. Phytomedicine. 2016 Nov 15;23(12):1434-1440. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987 Jan 5;40(1):35-9.