TargetMol

Pifithrin-β hydrobromide

Product Code:
 
TAR-T3637
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3637-2mg2mg£98.00
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TAR-T3637-5mg5mg£111.00
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TAR-T3637-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T3637-10mg10mg£139.00
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TAR-T3637-25mg25mg£193.00
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TAR-T3637-50mg50mg£250.00
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TAR-T3637-100mg100mg£337.00
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Further Information

Bioactivity:
Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).
CAS:
511296-88-1
Formula:
C16H17BrN2S
Molecular Weight:
349.29
Pathway:
Apoptosis; Cell Cycle/Checkpoint
Purity:
0.9962
SMILES:
Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1
Target:
Ferroptosis; p53

References

Da Pozzo E , La Pietra V , Cosimelli B , et al. p53 Functional Inhibitors Behaving Like Pifithrin-? Counteract the Alzheimer Peptide Non-?-amyloid Component Effects in Human SH-SY5Y Cells[J]. ACS Chemical Neuroscience, 2014, 5(5):390-399. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. Xu D, Xu Y, Cui Q, et al. Cold atmospheric plasma as a potential tool for multiple myeloma treatment. Oncotarget. 2018, 9(26): 18002 Feng F, Wang Z, Li R, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2[J]. Biomedicine & Pharmacotherapy. 2019 Apr;112:108669. Feng F, Wang Z, Li R, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. Biomedicine & Pharmacotherapy. 2019 Apr;112:108669