TargetMol

Filipin II

Product Code:
 
TAR-T36784
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36784-5mg5mg£2,855.00
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Further Information

Bioactivity:
Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]
CAS:
38620-77-8
Formula:
C35H58O10
Molecular Weight:
638.839
Purity:
0.98
SMILES:
CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)C(C)=CC=CC=CC=CC=C[C@H](O)[C@@H](C)OC1=O

References

Balcavage, W.X., Beale, M., Chasen, B., et al. Effect of filipin on rat-liver and yeast mitochondria. Biochim. Biophys. Acta. 162(4), 525-532 (1968). Bergy, M.E., and Eble, T.E. The filipin complex. Biochemistry 7(2), 653-659 (1968). Sessa, G., and Weissmann, G. Effects of four components of the polyene antibiotic, filipin, on phospholipid spherules (liposomes) and erythrocytes. J. Biol. Chem. 243(16), 4364-4371 (1968).