TargetMol

A-740003

Product Code:
 
TAR-T3690
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3690-5mg5mg£98.00
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TAR-T3690-10mg10mg£113.00
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TAR-T3690-50mg50mg£128.00
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TAR-T3690-100mg100mg£162.00
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Further Information

Bioactivity:
A 740003 is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuroblastoma tumor growth in mice.
CAS:
861393-28-4
Formula:
C26H30N6O3
Molecular Weight:
474.565
Pathway:
Neuroscience; Membrane transporter/Ion channel
Purity:
0.9951
SMILES:
COc1ccc(CC(=O)NC(NC(Nc2cccc3ncccc23)=NC#N)C(C)(C)C)cc1OC
Target:
P2X Receptor

References

Tian C, Han X, He L, et al. Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage[J]. Molecular and Cellular Biochemistry. 2020: 1-14. Kim, J., Ryu, H., & Kang, T. (2011). P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-?-mediated pathway in the rat hippocampus following status epilepticus.?Journal Of Neuroinflammation,?8(1), 62. doi: 10.1186/1742-2094-8-62 Honore P, et al. A-74202003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Th Tian C, Han X, He L, et al. Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Molecular and Cellular Biochemistry. 2020: 1-14 Donnelly-Roberts DL, et al. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.Br J Pharmacol. 2009 Aug;157(7):1203-14. Epub 2009 Jun 22. Xiao Z, Xu M, Lan L, et al. Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis. Molecular Pain. 2022, 18: 17448069221106844