TargetMol

PKUMDL-LC-101-D04

Product Code:
 
TAR-T36935
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36935-1mg1mg£135.00
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Quantity:
TAR-T36935-5mg5mg£303.00
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TAR-T36935-10mg10mg£414.00
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TAR-T36935-25mg25mg£621.00
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TAR-T36935-50mg50mg£849.00
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Quantity:
TAR-T36935-100mg100mg£1,099.00
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Quantity:
TAR-T36935-500mg500mg£2,175.00
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Further Information

Bioactivity:
PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.
CAS:
2143896-83-5
Formula:
C14H22N4O2S2.HCl
Molecular Weight:
378.9
Pathway:
oxidation-reduction
Purity:
0.98
SMILES:
S=C(NC1CCCC1)NC2=CC=C(S(NCCN)(=O)=O)C=C2.Cl
Target:
GPX

References

Li C, et al. Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4. J Med Chem. 2019;62(1):266-275.