TargetMol

Naphthofluorescein

Product Code:
 
TAR-T36953
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36953-10mg10mg£104.00
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TAR-T36953-50mg50mg£171.00
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Further Information

Bioactivity:
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP. Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
CAS:
61419-02-1
Formula:
C28H16O5
Molecular Weight:
432.4
Purity:
0.98
SMILES:
[Na].[Na].Oc1ccc2c(ccc3c2Oc2c4ccc(O)cc4ccc2C23OC(=O)c3ccccc23)c1