TargetMol

MS 15203

Product Code:
 
TAR-T37131
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.
CAS:
73912-52-4
Formula:
C12H11NO5
Molecular Weight:
249.222
Purity:
0.98
SMILES:
CC(=C)C(=O)Nc1cc(cc(c1)C(O)=O)C(O)=O

References

Wardman et al (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake Sci.Signal. 9 PMID:27245612