TargetMol

Carbamazepine 10,11-epoxide

Product Code:
 
TAR-T37149
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37149-5mg5mg£102.00
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TAR-T37149-10mg10mg£122.00
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TAR-T37149-25mg25mg£173.00
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TAR-T37149-50mg50mg£225.00
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TAR-T37149-100mg100mg£301.00
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TAR-T37149-200mg200mg£417.00
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TAR-T37149-500mg500mg£643.00
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Further Information

Bioactivity:
Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine[1][2].It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively[1].Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.2It has been found in wastewater effluent[3].
CAS:
36507-30-9
Formula:
C15H12N2O2
Molecular Weight:
252.273
Purity:
0.98
SMILES:
NC(=O)N1c2ccccc2C2OC2c2ccccc12

References

Kerr, B.M., Thummel, K.E., Wurden, C.J., et al.Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formationBiochem. Pharmacol.47(11)1969-1979(1994) Bourgeois, B.F., and Wad, N.Individual and combined antiepileptic and neurotoxic activity of carbamazepine and carbamazepine-10,11-epoxide in miceJ. Pharmacol. Exp. Ther.231(2)411-415(1984) Miao, X.-S., Yang, J.-J., and Metcalfe, C.D.Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plantEnviron. Sci. Technol.39(19)7469-7475(2005)