TargetMol

Enpatoran hydrochloride

Product Code:
 
TAR-T37287
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37287-5mg5mg£337.00
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TAR-T37287-1mL1 mL * 10 mM (in DMSO)£364.00
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TAR-T37287-10mg10mg£524.00
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TAR-T37287-25mg25mg£970.00
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Further Information

Bioactivity:
Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research[1].
CAS:
2101945-93-9
Formula:
C16H16ClF3N4
Molecular Weight:
356.77
Purity:
0.98
SMILES:
N/A

References

Jaromir Vlach, et al. Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity. J Pharmacol Exp Ther. 2020 Dec 16;JPET-AR-2020-000275.