TargetMol

Protectin D1

Product Code:
 
TAR-T37379
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T37379-5mg5mg£2,054.00
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TAR-T37379-50mg50mg£4,070.00
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TAR-T37379-100mg100mg£5,693.00
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This product comes from: United States.
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Further Information

Bioactivity:
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions. It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 μg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation. It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.
CAS:
660430-03-5
Formula:
C22H32O4
Molecular Weight:
360.5
Purity:
0.98
SMILES:
CC/C=CC[C@H](O)/C=CC=CC=C[C@H](O)C/C=CC/C=CCCC(O)=O