TargetMol

Aptiganel hydrochloride

Product Code:
 
TAR-T38068
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.
CAS:
137160-11-3
Formula:
C20H21N3.HCl
Molecular Weight:
339.86
Purity:
0.98
SMILES:
N=C(N(C)C3=CC=CC(CC)=C3)NC1=C2C(C=CC=C2)=CC=C1.Cl

References

Reddy et al (1994) Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 37 260 PMID:8295213 Sch?bitz et al (2000) The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31 1709 PMID:10884477