TargetMol

GSK143

Product Code:
 
TAR-T38626
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38626-5mg5mg£850.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC 50 of 7.5. GSK143 inhibits phosphorylated Erk (pErk: pIC 50 =7.1). GSK143 reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice.
CAS:
1240390-27-5
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Abraham M Varghese, et al. Highly Selective SYK Inhibitor, GSK143, Abrogates Survival Signals in Chronic Lymphocytic Leukaemia. Br J Haematol. 2018 Sep;182(6):927-930. John Liddle, et al. Discovery of GSK143, a Highly Potent, Selective and Orally Efficacious Spleen Tyrosine Kinase Inhibitor. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. Sjoerd H W van Bree, et al. Inhibition of Spleen Tyrosine Kinase as Treatment of Postoperative Ileus. Gut. 2013 Nov;62(11):1581-90.