TargetMol

Agnuside

Product Code:
 
TAR-T3868
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3868-1mg1mg£107.00
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TAR-T3868-5mg5mg£149.00
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TAR-T3868-1mL1 mL * 10 mM (in DMSO)£159.00
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TAR-T3868-10mg10mg£189.00
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TAR-T3868-25mg25mg£270.00
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TAR-T3868-50mg50mg£367.00
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TAR-T3868-100mg100mg£511.00
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Further Information

Bioactivity:
Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.
CAS:
11027-63-7
Formula:
C22H26O11
Molecular Weight:
466.439
Pathway:
Neuroscience; Membrane transporter/Ion channel; GPCR/G Protein; Immunology/Inflammation
Purity:
0.9981
SMILES:
OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@H]3[C@H](O)C=C(COC(=O)c4ccc(O)cc4)[C@@H]23)[C@H](O)[C@@H](O)[C@@H]1O
Target:
COX; Prostaglandin Receptor; P-gp

References

Pandey A, et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflamm Res. 2012 Apr;61(4):293-304. Suksamrarn A, et al. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med. 2002 Jan;68(1):72-3. Okuyama E, et al. Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):655-62. Najar IA, et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytother Res. 2010 Mar;24(3):454-8. Hu Y, et al. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol. 2007 Sep;59(9):1307-12.