TargetMol

Varespladib sodium

Product Code:
 
TAR-T39173
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A 2 (sPLA 2 ) inhibitor with an IC 50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC 50 s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
CAS:
172733-42-5
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Hori Y, et al. Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61. Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.