TargetMol

TAK-418

Product Code:
 
TAR-T39252
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39252-1mg1mg£258.00
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TAR-T39252-5mg5mg£535.00
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TAR-T39252-1mL1 mL * 10 mM (in DMSO)£615.00
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TAR-T39252-10mg10mg£804.00
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TAR-T39252-25mg25mg£1,572.00
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TAR-T39252-50mg50mg£2,095.00
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Quantity:
TAR-T39252-100mg100mg£2,785.00
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This product comes from: United States.
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Further Information

Bioactivity:
TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC 50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
CAS:
1818252-53-7
Formula:
0
Molecular Weight:
0
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
0
Target:
Histone Demethylase

References

Baba R, et al. LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models. Sci Adv. 2021;7(11):eaba1187. Zhang L, et al. Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome. Mol Ther Methods Clin Dev. 2021;20:779-791.