TargetMol

GNE-274

Product Code:
 
TAR-T39916
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39916-5mg5mg£670.00
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Further Information

Bioactivity:
GNE-274 is a non-degrader that is structurally related to GDC-0927 (ER degrader). GNE-274 does not induce ER turnover and functions as a partial ER agonist in breast cancer cell lines. GNE-274 increase chromatin accessibility at ER-DNA binding sites, while GDC-0927 do not. GNE-274 is a potent inhibitor of ER-ligand binding domain (LBD). GNE-274 can be used for cancer research.
CAS:
2369048-69-9
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Jane?Guan, et al. Abstract NG05: Not all ?SERDs? are equal: Context-independent ER degradation and full ER antagonism define the next generation of ER therapeutics. Cancer research. Jane Guan, et al. Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility. Cell. 2019 Aug 8;178(4):949-963.e18.