TargetMol

Berbamine

Product Code:
 
TAR-T3S0807
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S0807-5mg5mg£107.00
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TAR-T3S0807-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T3S0807-10mg10mg£128.00
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TAR-T3S0807-25mg25mg£189.00
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TAR-T3S0807-50mg50mg£244.00
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TAR-T3S0807-100mg100mg£331.00
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Further Information

Bioactivity:
1. Berbamine has high binding affinity toward the (GGA);G-quadruplex. 2. Berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII. 3. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia. 4. Berbamine can enhance the antitumor activity of gemcitabine by inhibiting cell growth and inducing apoptosis, possibly through the regulation of the expression of apoptosis-related proteins and the activation of TGF-β/Smad signaling pathway. 5. Berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel.
CAS:
478-61-5
Formula:
C37H40N2O6
Molecular Weight:
608.735
Pathway:
Neuroscience; Autophagy; NF-κb
Purity:
0.9964
SMILES:
COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5cc(C[C@H]6N(C)CCc7cc(OC)c(OC)c(Oc1cc23)c67)ccc5O)cc4
Target:
CaMK; NF-κB; Autophagy

References

Jin X , Wu Y . Berbamine Enhances the Antineoplastic Activity of Gemcitabine in Pancreatic Cancer Cells by Activating Transforming Growth Factor-?/Smad Signaling[J]. The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology, 2014, 297(5).