TargetMol

kuwanon G

Product Code:
 
TAR-T3S1612
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3S1612-1mg1mg£173.00
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TAR-T3S1612-5mg5mg£328.00
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TAR-T3S1612-1mL1 mL * 10 mM (in DMSO)£414.00
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TAR-T3S1612-10mg10mg£454.00
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TAR-T3S1612-25mg25mg£691.00
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TAR-T3S1612-50mg50mg£914.00
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TAR-T3S1612-100mg100mg£1,211.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
CAS:
75629-19-5
Formula:
C40H36O11
Molecular Weight:
692.717
Pathway:
Neuroscience; Microbiology/Virology; Metabolism; GPCR/G Protein
Purity:
0.9847
SMILES:
CC(C)=CCc1c(oc2c([C@H]3C=C(C)C[C@H]([C@@H]3C(=O)c3ccc(O)cc3O)c3ccc(O)cc3O)c(O)cc(O)c2c1=O)-c1ccc(O)cc1O
Target:
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase

References

Paudel P, Yu T , Seong SH, et al. Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study[J]. International Journal of Molecular Sciences, 2018, 19(5):1542-. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891.