TargetMol

RET-IN-4

Product Code:
 
TAR-T40097
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40097-5mg5mg£850.00
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Further Information

Bioactivity:
RET-IN-4 is a potent, selective and orally active RET inhibitor with IC 50 s of 1.29 nM, 1.97 nM, and 0.99 nM for RET (WT) , RET (V804M) , and RET (M918T) , respectively. RET-IN-4 exhibits better kinases selectivity against JAK2 (IC 50 of 4.4 nM) and FLT3 (IC 50 of 30.8 nM). RET-IN-4 has anticancer effects.
CAS:
2436473-55-9
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Zhibo Luo, et al. Discovery and Optimization of Selective RET Inhibitors via Scaffold Hopping. Bioorg Med Chem Lett. 2021 May 28;128149.