TargetMol

SR-0813

Product Code:
 
TAR-T40229
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40229-1mg1mg£204.00
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TAR-T40229-5mg5mg£356.00
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TAR-T40229-1mL1 mL * 10 mM (in DMSO)£438.00
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TAR-T40229-10mg10mg£533.00
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TAR-T40229-25mg25mg£812.00
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TAR-T40229-50mg50mg£1,083.00
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Quantity:
TAR-T40229-100mg100mg£1,420.00
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Further Information

Bioactivity:
SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC 50 and EC 50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC 50 and EC 50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity ( K d =3.5 μM) than ENL YEATS ( K d =30 nM). SR-0813 can be used for the research of acute leukemia.
CAS:
2597186-19-9
Formula:
0
Molecular Weight:
0
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
0
Target:
Epigenetic Reader Domain

References

Garnar-Wortzel L, et al. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7(5):815-830.