TargetMol

Meclizine

Product Code:
 
TAR-T40652
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T40652-1mg1mg£227.00
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TAR-T40652-5mg5mg£431.00
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TAR-T40652-10mg10mg£600.00
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TAR-T40652-25mg25mg£863.00
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TAR-T40652-50mg50mg£1,187.00
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TAR-T40652-100mg100mg£1,581.00
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Further Information

Bioactivity:
Meclizine (Meclozine), an antihistamine , reversibly inhibits the interaction of histamine at the H1 receptors . Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood?brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease.
CAS:
569-65-3
Formula:
C25H27ClN2
Molecular Weight:
390.96
Pathway:
GPCR/G Protein|Immunology/Inflammation|Neuroscience
Purity:
0.98
SMILES:
Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1
Target:
Histamine Receptor

References

Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness. Clinical Medicine Insights: Therapeutics. 2011;3. Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2(9):1090-101. Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20(2):294-300. Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR.Mol Endocrinol. 2004 Oct;18(10):2402-8.