TargetMol

MLS1082

Product Code:
 
TAR-T41014
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41014-5mg5mg£850.00
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Further Information

Bioactivity:
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC 50 of 123 nM for DA-stimulated G protein signaling.
CAS:
883958-36-9
Formula:
C24H23N3O2
Molecular Weight:
385.467
Purity:
0.98
SMILES:
Cn1c2ccccc2c(=O)c2c1nc(C1CCCCC1)n(-c1ccccc1)c2=O

References

Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209. Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696.