TargetMol

Compound 48/80

Product Code:
 
TAR-T41103
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T41103-5mg5mg£850.00
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This product comes from: United States.
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Further Information

Bioactivity:
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways."
CAS:
94724-12-6
Formula:
C32H50Cl2N3O3
Molecular Weight:
595.67
Purity:
0.98
SMILES:
[H].[H].[H].Cl.Cl.CNCCc1ccc(OC)c(Cc2cc(CCNC)cc(Cc3cc(CCNC)ccc3OC)c2OC)c1

References

Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. Wang YH, Tach? Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124.