TargetMol

EM 163

Product Code:
 
TAR-T41142
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41142-1mg1mg£169.00
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TAR-T41142-5mg5mg£306.00
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TAR-T41142-10mg10mg£386.00
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TAR-T41142-1mL1 mL * 10 mM (in DMSO)£440.00
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TAR-T41142-25mg25mg£599.00
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TAR-T41142-50mg50mg£823.00
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TAR-T41142-100mg100mg£1,091.00
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TAR-T41142-500mg500mg£2,119.00
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Further Information

Bioactivity:
EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine productionin vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neuronsin vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).
CAS:
1206480-93-4
Formula:
0
Molecular Weight:
0
Pathway:
Immunology/Inflammation|MAPK
Purity:
0.98
SMILES:
0
Target:
IL Receptor|p38 MAPK|MyD88

References

Lucas K, et al. Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol Neurobiol. 2013;48(1):190-204. Kissner TL, et al. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One. 2012;7(7):e40773. Prieto GA, et al. Inhibition of LTP-Induced Translation by IL-1? Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites. ACS Chem Neurosci. 2019;10(3):1197-1203.