TargetMol

K34c

Product Code:
 
TAR-T41151
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41151-5mg5mg£850.00
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Further Information

Bioactivity:
K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltrationin vivoand reduces cell adhesion on fibronectin.
CAS:
939769-93-4
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Kuonen et al (2018) TGF-?, fibronectin and integrin ?5?1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 138 2432 PMID: 29758283 Martinkova et al (2010) ?5?1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 127 1240 PMID: 20099278 Renner et al (2016) Expression/activation of ?5?1 integrin is linked to the ?-catenin signaling pathway to drive migration in glioma cells. Oncotarget 7 62194 PMID: 27613837 Heckmann et al (2007) Probing integrin selectivity: rational design of highly active and selective ligands for the ?5?1 and ?v?3 integrin receptor. Angew.Chem.Int.Ed.Engl 46 3571 PMID: 17394271