TargetMol

FC 11

Product Code:
 
TAR-T41164
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41164-5mg5mg£403.00
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Further Information

Bioactivity:
FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC?Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.
CAS:
2271035-37-9
Formula:
0
Molecular Weight:
0
Purity:
0.98
SMILES:
0

References

Gao et al (2019) Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs. ACS.Med.Chem.Lett. 11 1855 PMID: 33062164