TargetMol

AY 77

Product Code:
 
TAR-T41190
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41190-1mg1mg£621.00
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Quantity:
TAR-T41190-5mg5mg£1,259.00
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Quantity:
TAR-T41190-10mg10mg£1,669.00
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TAR-T41190-25mg25mg£2,448.00
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Quantity:
TAR-T41190-50mg50mg£3,275.00
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Quantity:
TAR-T41190-100mg100mg£4,400.00
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Quantity:
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Further Information

Bioactivity:
AY 77 is a potent PAR2 biased agonist. AY 77 exhibits bias for Ca2+over ERK1/2 signaling (EC50values are 40 nM for Ca2+release versus 2 μM for ERK1/2 phosphorylation). Shows selectivity for PAR2 over PAR1. Promotes migration of human breast cancer cellsin vitro.
CAS:
1835734-92-3
Formula:
0
Molecular Weight:
0
Pathway:
Metabolism|Membrane transporter/Ion channel|GPCR/G Protein|MAPK
Purity:
0.98
SMILES:
0
Target:
Calcium Channel|ERK|Protease-activated Receptor

References

Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017;12(5):1217-1226. Yau MK, et al. Potent Small Agonists of Protease Activated Receptor ACS Med Chem Lett. 2015;7(1):105-110.